RESEARCH

Evidence synthesis and decision modelling is a rapidly evolving discipline with growing needs across a wide variety of settings.

 

We take great pride in both the research we conduct for clients - including Pharma, multilateral health agencies and national and local agencies - as well as the ongoing research we conduct in academic settings. 

 

By continuing to pursue our passion for methodological rigour and development, we ensure that we can provide the best services to our clients. 

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Publications

Methodology

 

Kanters, S., Karim, M. E., Thorlund, K., Anis, A., & Bansback, N. (2021). When does the use of individual patient data in network meta-analysis make a difference? A simulation study. BMC Med. Res. Methodol. 21(1), 21 (2021). 


Kanters, S., Karim, M. E., Thorlund, K., Anis, A. H., Zoratti, M., & Bansback, N. Comparing the use of aggregate data and various methods of integrating individual patient data to network meta-analysis and its application to first-line ART. BMC Med. Res. Methodol. 21(1), 60 (2021). 

Kanters, S., Thorlund, K., Mills, E.J.: Ethical testing of experimental Ebola treatments. JAMA 313(4), 421-422 (2015). 

Sadeghirad, B., Foroutan, F., Zoratti, M. J., Busse, J. W., Brignardello-Petersen, R., Guyatt, G., & Thabane, L. Theory and practice of Bayesian and frequentist frameworks for network meta-analysis. BMJ EBM Advance online publication (2022).

 
Zoratti, M. J., Pickard, A. S., Stalmeier, P., Ollendorf, D., Lloyd, A., Chan, K., Husereau, D., Brazier, J. E., Krahn, M., Levine, M., Thabane, L., Xie, F., & Health Utility Book (HUB) Working Group. Evaluating the conduct and application of health utility studies: a review of critical appraisal tools and reporting checklists. Eur J Health Econ 22(5), 723–733 (2021). 


Zoratti, M. J., Chan, K., Husereau, D., Krahn, M., Levine, M., Thabane, L., Xie, F., & Health Utility Book (HUB) Working Group (2021). Towards Transparency in the Selection of Published Health Utility Inputs in Cost-Utility Analyses: The Health Utility Application Tool (HAT). PharmacoEconomics 39(9), 1075–1084 (2021).


Kovic, B., Zoratti, M. J., Michalopoulos, S., Silvestre, C., Thorlund, K., & Thabane, L. Deficiencies in addressing effect modification in network meta-analyses: a meta-epidemiological survey. J. Clin. Epidemiol. 88, 47–56 (2017). 


Kanters, S., Ford, N., Druyts, E., Thorlund, K., Mills, E.J., Bansback, N.: Use of network meta-analysis in clinical guidelines. Bull World Health Organ 94(10), 782-784 (2016a). 


Mills, E.J., Kanters, S., Thorlund, K., Chaimani, A., Veroniki, A.A., Ioannidis, J.P.: The effects of excluding treatments from network meta-analyses: survey. BMJ (Clinical research ed.) 347, f5195 (2013). 

Oncology

Ghione, P., Palomba, M. L., Patel, A. R., Bobillo, S., Deighton, K., Jacobson, C. A., Nahas, M., Hatswell, A. J., Jung, A. S., Kanters, S., Snider, J. T., Neelapu, S. S., Ribeiro, M. T., Brookhart, M. A., Ghesquieres, H., Radford, J., & Gribben, J. G. Comparative effectiveness of ZUMA-5 (axi-cel) vs SCHOLAR-5 external control in relapsed/refractory follicular lymphoma. Blood 140(8), 851–860 (2022). 


Ghione, P., Palomba, M. L., Ghesquieres, H., Bobillo, S., Patel, A. R., Nahas, M., Kanters, S., Deighton, K., Hatswell, A., Ma, L., Limbrick-Oldfield, E. H., Snider, J. T., Wade, S. W., Riberio, M. T., Radford, J., Beygi, S., & Gribben, J. Treatment patterns and outcomes in relapsed/refractory follicular lymphoma: results from the international SCHOLAR-5 study. Haematologica Advance online publication (2022). 


Zoratti, M. J., Devji, T., Levine, O., Thabane, L., & Xie, F. (2019). Network meta-analysis of therapies for previously untreated advanced BRAF-mutated melanoma. Cancer Treat Rev. 74, 43–48 (2019).


Chiu, C.G., Smith, D., Salters, K.A., Zhang, W., Kanters, S., Milan, D., Montaner, J.S.G., Coldman, A., Hogg, R.S., Wiseman, S.M.: Overview of cancer incidence and mortality among people living with HIV/AIDS in British Columbia, Canada: Implications for HAART use and NADM development. BMC Cancer 17(1), 270 (2017). 

HIV & HCV

Oru, E., Trickey, A., Shirali, R., Kanters, S., & Easterbrook, P. Decentralisation, integration, and task-shifting in hepatitis C virus infection testing and treatment: a global systematic review and meta-analysis. Lancet Global Health 9(4), e431–e445 (2021). 

Kanters, S., Park, J.J., Chan, K., Socias, M.E., Ford, N., Forrest, J.I., Thorlund, K., Nachega, J.B., Mills, E.J.: Interventions to improve adherence to antiretroviral therapy: a systematic review and network meta-analysis. Lancet HIV 4(1), e31-e40 (2017a). 


Kanters, S., Socias, M.E., Paton, N.I., Vitoria, M., Doherty, M., Ayers, D., Popoff, E., Chan, K., Cooper, D.A., Wiens, M.O., Calmy, A., Ford, N., Nsanzimana, S., Mills, E.J.: Comparative efficacy and safety of second-line antiretroviral therapy for treatment of HIV/AIDS: a systematic review and network meta-analysis. Lancet HIV 4(10), e433-e441 (2017b).

 
Kanters, S., Vitoria, M., Doherty, M., Socias, M.E., Ford, N., Forrest, J.I., Popoff, E., Bansback, N., Nsanzimana, S., Thorlund, K., Mills, E.J.: Comparative efficacy and safety of first-line antiretroviral therapy for the treatment of HIV infection: a systematic review and network meta-analysis. Lancet HIV 3(11), e510-e520 (2016b). 


Nsanzimana, S., Remera, E., Kanters, S., Chan, K., Forrest, J.I., Ford, N., Condo, J., Binagwaho, A., Mills, E.J.: Life expectancy among HIV-positive patients in Rwanda: a retrospective observational cohort study. Lancet Global Health 3(3), e169-177 (2015). 


Nsanzimana, S., Binagwaho, A., Kanters, S., Mills, E.J.: Churning in and out of HIV care. Lancet HIV 1(2), e58-e59 (2014). 


Kanters, S., Renaud, F., Rangaraj, A., Zhang, K., Limbrick-Oldfield, E., Hughes, M., Ford, N., & Vitoria, M. Evidence synthesis evaluating body weight gain among people treating HIV with antiretroviral therapy - a systematic literature review and network meta-analysis. EClinicalMedicine 48, 101412 (2022). 

 

 

Precision Medicine & Rare Diseases
 

Johnston, B.C., Kanters, S., Bandayrel, K., Wu, P., Naji, F., Siemieniuk, R.A., Ball, G.D., Busse, J.W., Thorlund, K., Guyatt, G., Jansen, J.P., Mills, E.J.: Comparison of weight loss among named diet programs in overweight and obese adults: a meta-analysis. JAMA 312(9), 923-933 (2014). 


Kanters, S., Wilkinson, L., Vrazic, H., Sharma, R., Lopes, S., Popoff, E., Druyts, E.: Comparative efficacy of once-weekly semaglutide versus SGLT-2 inhibitors in patients inadequately controlled with one to two oral antidiabetic drugs: a systematic literature review and network meta-analysis. BMJ Open 9(7), e023458 (2019). 


Ayers, D., Kanters, S., Goldgrub, R., Hughes, M., Kato, R., Kragh, N.: Network meta-analysis of liraglutide versus dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes in Japanese patients. Curr Med Res Opin 33(9), 1653-1661 (2017). 


Zoratti, M. J., Siddiqua, A., Morassut, R. E., Zeraatkar, D., Chou, R., van Holten, J., Xie, F., & Druyts, E. Pangenotypic direct acting antivirals for the treatment of chronic hepatitis C virus infection: A systematic literature review and meta-analysis. EClinicalMedicine 18, 100237 (2020).


Ortiz, A., Kanters, S., Hamed, A., DasMahapatra, P., Poggio, E., Maski, M., Aguiar, M., Ponce, E., Jansen, J. P., Ayers, D., Goldgrub, R., & Desnick, R. J. Agalsidase beta treatment slows estimated glomerular filtration rate loss in classic Fabry disease patients: results from an individual patient data meta-analysis. Clin. Kidney J 14(4), 1136–1146 (2020). 


Berger, K.I., Kanters, S., Jansen, J.P., Stewart, A., Sparks, S., Haack, K.A., Bolzani, A., Siliman, G., Hamed, A.: Forced vital capacity and cross-domain late-onset Pompe disease outcomes: an individual patient-level data meta-analysis. J Neurol 266(9), 2312-2321 (2019). 


McInnes, I.B., Nash, P., Ritchlin, C., Choy, E.H., Kanters, S., Thom, H., Gandhi, K., Pricop, L., Jugl, S.M.: Secukinumab for psoriatic arthritis: comparative effectiveness versus licensed biologics/apremilast: a network meta-analysis. J Comp Eff Res 7(11), 1107-1123 (2018). 

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